Located east of the Tennessee state line and west of the Piedmont, Western North Carolina contains very few major urban centers. Asheville, North Carolina, located in the region's center, is the area's largest city and most prominent commercial hub. The Foothills region of the state is loosely defined as the area along Western North Carolina's eastern boundary; this region consists of a transitional terrain of hills between the Appalachians and the Piedmont Plateau of central North Carolina. The Eastern Band of Cherokee Indians have a reservation situated in the Western North Carolina region, adjacent to the Great Smoky Mountains National Park.
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